| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
|
| País: |
Brazil
|
| Título: |
Myeloproliferative syndrome of monosomy 7: a brief report
|
| Autores: |
Marques-Salles,Terezinha de Jesus
Soares-Ventura,Eliane Maria
Oliveira,Nathalia Lopes de
Silva,Mariluze
Assis,Reijane
Morais,Vera Lúcia Lins de
Otero,Luize
Fernandez,Teresa
Pombo-de-Oliveira,Maria do Socorro
Muniz,Maria Tereza Cartaxo
Santos,Neide
|
| Data: |
2008-01-01
|
| Ano: |
2008
|
| Palavras-chave: |
Leukemia
Monosomy 7
Myeloproliferative syndrome
|
| Resumo: |
We report the case of a five-month-old black male infant who had recurrent episodes of respiratory infections and also presented anemia and enlargements of the spleen, liver and lymphnodes. Hematological analysis revealed morphological abnormalities with megaloblastic dyserythropoiesis, while fetal hemoglobin assaying showed normal levels. Conventional and molecular cytogenetic analysis revealed monosomy of chromosome 7. Despite all therapeutic efforts during allogenic bone marrow transplantation, the child died due to generalized infection. The clinical and genetic distinctions between monosomy 7 syndrome and myelodysplastic disorders in childhood are discussed.
|
| Tipo: |
Info:eu-repo/semantics/other
|
| Idioma: |
Inglês
|
| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000100007
|
| Editor: |
Sociedade Brasileira de Genética
|
| Relação: |
10.1590/S1415-47572008000100007
|
| Formato: |
text/html
|
| Fonte: |
Genetics and Molecular Biology v.31 n.1 2008
|
| Direitos: |
info:eu-repo/semantics/openAccess
|
